CHAMPAIGN, Ill. — New research found the most common form of breast cancer presents differing metabolic signatures in the blood of African American women with estrogen receptor-positive breast cancer compared with non-Hispanic white women. The scientists also identified a protein – negative elongation factor complex E – that was linked with higher mortality rates among African American women with estrogen receptor-positive breast cancer. 

CHAMPAIGN, Ill. — Patients with squamous cell carcinoma of the head or neck were 93% less likely to die of any cause during the first three years after diagnosis if they ate a healthy diet high in nutrients found to deter chronic disease, researchers found in a recent study.

CHAMPAIGN, Ill. — A multidisciplinary team at the University of Illinois Urbana-Champaign has devised a new approach to 3D imaging that captures DNA methylation, a key epigenetic change associated with learning in the brain. The scientists say their proof-of-concept study in pigs will easily translate to humans, as the new method relies on standard MRI technology and biological markers already in use in human medicine.

This week’s 5 Questions Friday features Matthew Dean, assistant professor in the Department of Animal Sciences. Dean's group studies the female reproductive system, with the goal of improving fertility in both humans and livestock.

What motivates you in your work?

URBANA, Ill. – Postmenopausal women have increased risk of non-alcoholic fatty liver disease due to loss of estrogen from metabolic changes. A high-fat diet further exacerbates the disease, which can progress to cirrhosis and liver failure. Hormone replacement therapy (HRT) is an effective treatment, but it carries increased risk of breast cancer, uterine cancers, and cardiovascular disease.

URBANA, Ill. – If you’ve ever been to an eye doctor, there’s a good chance you’ve felt the sudden puff of air to the eye that constitutes a traditional test for glaucoma. It’s no one’s favorite experience, but the puff is non-invasive and harmless.

URBANA, Ill. ­– As we move through life, our bodies get older. Aging is inevitable, but how fast it happens can vary considerably. Physical and environmental stressors can accelerate the process, and culture may interact with biology in ways that are not fully explored. 

URBANA, Ill. – As the owner of a human body, you’re carrying trillions of microbes with you everywhere you go. These microscopic organisms aren’t just hitching a ride; many of them perform essential chemical reactions that regulate everything from our digestion to our immune system to our moods.

URBANA, Ill. – Before humans can benefit from new drug therapies and nutritional additives, scientists test their safety and efficacy in animals, typically mice and rats. But, as much as they’ve done for biomedical research, rodents aren’t always the best research model for studies on neonatal brain development and nutrition. That’s where pigs can play an important role.

URBANA, Ill. – When scientists need to understand the effects of new infant formula ingredients on brain development, it’s rarely possible for them to carry out initial safety studies with human subjects. After all, few parents are willing to hand over their newborns to test unproven ingredients.