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Cholesterol metabolite induces production of cancer-promoting vesicles

CHAMPAIGN, Ill. — Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.

Reported in the journal Endocrinology, the discovery could lead to the development of new anti-cancer therapies, researchers say.

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Male piglets less resilient to stress when moms get sick during pregnancy

URBANA, Ill. – When pigs get hit with significant illnesses during key stages of pregnancy, their immune response may negatively affect developing piglets, making them less productive on the farm. New research from the University of Illinois shows that when those piglets – especially males – experience a second stressor in early life, they are at higher risk of neurodevelopmental and other neurological anomalies, putting them at an even greater disadvantage in production settings.

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Microbial gene discovery could mean greater gut health

URBANA, Ill. – As the owner of a human body, you’re carrying trillions of microbes with you everywhere you go. These microscopic organisms aren’t just hitching a ride; many of them perform essential chemical reactions that regulate everything from our digestion to our immune system to our moods.

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In pig brain development, nature beats nurture

URBANA, Ill. – Before humans can benefit from new drug therapies and nutritional additives, scientists test their safety and efficacy in animals, typically mice and rats. But, as much as they’ve done for biomedical research, rodents aren’t always the best research model for studies on neonatal brain development and nutrition. That’s where pigs can play an important role.

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How we can reduce food waste and promote healthy eating

URBANA, Ill. ­– Food waste and obesity are major problems in developed countries. They are both caused by an overabundance of food, but strategies to reduce one can inadvertently increase the other. A broader perspective can help identify ways to limit food waste while also promoting healthy nutrition, two University of Illinois researchers suggest.

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Illinois youth opioid use linked with other substance misuse, mental health issues

URBANA, Ill. ­– Opioid use has dramatically increased in the 21st century, especially among young adults. A new study from the University of Illinois provides insights on usage patterns among Illinois high school students to help inform prevention and treatment strategies.

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'Hunker down' stress genes boosted in women who live in violent neighborhoods

CHAMPAIGN, Ill. — The chronic stress of living in neighborhoods with high rates of violence and poverty alters gene activity in immune cells, according to a new study of low-income single Black mothers on the South Side of Chicago.

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New faculty expand ACES capacity in food and agricultural systems for global health

In an effort to dramatically strengthen and expand its capacity to improve global human and environmental health via the food system, the College of Agricultural, Consumer and Environmental Sciences (ACES) has hired a cluster of new faculty who bring strengths in these areas.

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How housing discrimination affects environmental inequality

URBANA, Ill. ­– Economists and urban planners generally agree that local pollution sources disproportionally impact racial minorities in the U.S. The reasons for this are largely unclear, but a University of Illinois study provides new insights into the issue. 

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3D microscopy clarifies understanding of body's immune response to obesity

URBANA, Ill. - Researchers who focus on fat know that some adipose tissue is more prone to inflammation-related comorbidities than others, but the reasons why are not well understood. Thanks to a new analytical technique, scientists are getting a clearer view of the microenvironments found within adipose tissue associated with obesity. This advance may illuminate why some adipose tissues are more prone to inflammation – leading to diseases like type 2 diabetes, cancer and cardiovascular disorders – and help direct future drug therapies to treat obesity.

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